Multi-modality imaging of uveal melanomas using combined PET/CT, high-resolution PET and MR imaging

作者：Beyer T^*; Pietrzyk U; Knoess C; Vollmar S; Wienhard K; Kracht L; Bockisch A; Maderwad S; Kuehl H; Fitzek M

来源：Nuklearmedizin, 2008, 47(2): 73-79.

DOI：10.3413/nukmed-0128

• PET/CT
• high-resolution PIT
• MRI
• uveal melanoma
• oncology
• image fusion
• proton therapy planning

We investigated the efficacy of combined FDG-PET/CT imaging far the diagnosis of small-size uveal melanomas and the feasibility of combining separate, high-resolution (H R) FDG-PET with MRI far its improved localization and detection. Patients, methods: 3 patients 06 small-size uveal melanomas (0.2-1.5 ml) were imaged on a combined whole-body PET/CT, a HR brain-PET, and a 1.5 TMRI. Static, contrast-enhanced FDG-PET/CT imaging was performed of head and torso with CT contrast enhancement. HR PIT imaging was performed in dynamic mode 0-180 min post-injection of FDG. MRI imaging was performed using a high-resolution smoll-loop-coil placed over the eye in question with T2-3D-TSE and T1 -3D-SE 06 18 ml Gd-controst. Patient had their eyes shaded during the scans. Lesion visibility on high-resolution FDG-PET images was graded for confidence: 1: none, 2: suggestive, 3: clear. Mean turnout activity was calculated far summed image frames that resulted in confidence grades 2 and 3. Whole-body FDG-PET/CT images were reviewed far lesions. PET-MRI and PET/ CT-MRI images of the head were co-registered far potentiolly improved lesion delineation. Results: Whole-body FDG-PET/CT images of 3/3 patients were positive for uveal melanomas and negative for disseminated disease. HR FDG-PET was positive already in the early time homes. One patient exhibited rising tumour activity with increasing uptake time on FDG-PET. MRI images of the eye were co-registered successfully to FDG-PET/CT using a manual alignment approach. Conclusions: Small-size uveal melanomas can be detected with whole-body FDG-PET/CT. This feasibility study suggest the exploration of HR FDG-PET in order to provide additional diagnostic information on patients with uveal melanomas. First results support extended uptake times and high-sensitivity PET far improved tumour visibility. MRI/PET co-registration is feasible and provides correlated functional and anatomical information that may support alternative therapy regimens.

• 出版日期2008
• 单位河北医科大学