A novel assembling complex of hydrobobic phthalocyanine-cyclodextrin: preparation, characterization, molecular modeling, and in vitro activity

作者：Lu, S.; Ma, Y. J.; Xuan, H. Y.; Wang, A.; Zhao, B.; Li, X. D.; Zhou, J. H.; Lin, Y.; Zhou, L.^*; Wei, S. H.

来源：RSC Advances, 2014, 4(104): 59759-59763.

DOI：10.1039/c4ra12654h

• HOST-GUEST INTERACTIONS
• CANCER PHOTODYNAMIC THERAPY
• BETA-CYCLODEXTRIN
• SILICON(IV) PHTHALOCYANINES
• ZINC(II) PHTHALOCYANINE
• DRUG-DELIVERY
• AQUEOUS-MEDIA
• PORPHYRIN
• PHOTOSENSITIZER
• NANOPARTICLES

The stable 4 : 1 host-guest complex of phthalocyanine (Pc) and hydroxypropyl-beta-cyclodextrin was designed, computer modeled and prepared. The complex formation can greatly increase water solubility, reactive oxygen generation ability, biocompatibility and, thereby, the in vitro phototoxicity of Pc to cancer cells.

• 出版日期2014
• 单位南京师范大学