ASSESSMENT OF CARCINOGENIC POTENTIAL OF SOFT DRINKS OF COLA, DIET COLA, ORANGE AND LEMON, PRODUCED IN THE CITY OF UBERLANDIA, MINAS GERAIS STATE, BRAZIL

作者：de Morais Cassio Resende^*; Vieira Thays Cunha; Borges Renato Mendonca; Melo Guimaraes Luisa Mariana; Barcelos Lucas Almeida; de Souza Fernanda Carvalho; Pimentel Leticia Santos; da Silva Jessica Costa; Vasconcelos Mirley Alves; Rodrigues Tamiris Sabrina; de Sousa Francielle Aparecida; Alves de Rezende Alexandre Azenha; Spano Mario Antonio; Bonetti Ana Maria

来源：Bioscience Journal, 2016, 32(4): 1025-1039.

• Mutagenicity wts
• Warts
• Drosophila melanogaster

Soft drinks are industrialized unfermented beverages, free of alcohol, carbonated, rich in artificial flavors and sugar. The intense consumption of such beverages can be related to not inheritable diseases such as caries, allergy, cellulite and stretch marks, gastrointestinal disorders, diabetes and cancer. The aim of this study was to evaluate the carcinogenic potential of different concentrations of soft drinks produced in the Uberlandia city, Minas Gerais State, Brazil, by means of Epithelial Tumor Detection Test using Drosophila melanogaster as a model. Third stage larvae descendants of crosses between D. melanogaster virgin females wts/TM3, sb(1) and males mwh/mwh were treated with different concentrations (0.83, 1.66 or 3.33 mL/g) of cola, diet cola, orange or lemon soft drinks. The total epithelial tumor rate observed in flies treated with 3.33 mL/g of cola and orange soft drinks was higher than the negative control. The diet cola and lemon caused no significant increase in the overall frequency of epithelial tumors in D. melanogaster. In conclusion, in these experimental conditions, the cola and orange base soft drinks demonstrated carcinogenic potential in somatic cells of D. melanogaster in the concentration of 3.33 mL/g.

• 出版日期2016-8