Antioxidant activity and controlled drug delivery potential of tragacanth gum-cl-poly (lactic acid-co-itaconic acid) hydrogel

作者：Gupta Vinod Kumar^*; Sood Swadeep; Agarwal Shilpi; Saini Adesh K; Pathania Deepak^*

来源：International Journal of Biological Macromolecules, 2018, 107: 2534-2543.

DOI：10.1016/j.ijbiomac.2017.10.138

• Tragacanth gum
• Itaconic acid
• Lactic acid
• Antimicrobial
• Targeted drug release
• Antioxidant

Tragacanth gum-cl-poly (lactic acid-co-itaconic acid) (TG-cl-p(LA-co-IA)) hydrogel is synthesized through graft copolymerization reaction using microwave assisted technique. The synthesized hydro gel was characterised using various analytical and characterization techniques such as FTIR, FESEM, XRD, TGA, TEM and SEM. It was observed that, the maximum percentage swelling (P-s) of the hydrogel was 311.61% after 6 h at room temperature and 298.06% after 3 h at 60 degrees C and TG-cl-p(LA-co-IA) exhibited highest Amoxicillin loading (73%) in double distilled waterafter 24 h. From the controlled release studies, it was evident that maximum drug release of about 96% took place at pH 2.2 = after 6 h. The synthesized hydrogel also showed mild antioxidant properties and 43.85% of free radical scavenging was occurred at a concentration of 640 mu g/mL and hence it can be effectively used to reduce the oxidative stresses. In addition to this, the antibacterial studies also showed that it is more effective against S. aureus.

• 出版日期2018-2