Asymmetric Synthesis of a New Salen Type-titanium Complex as the Catalyst for Asymmetric Trimethylsilylcyanation of Aldehydes

作者：Lin Zheng Chang; Chen Chinpiao^*

来源：Journal of the Chinese Chemical Society, 2010, 57(4A): 726-737.

DOI：10.1002/jccs.201000101

• Asymmetric synthesis
• Diels-Alder reaction
• Curtius rearrangement
• Trimethylsilylcyanation

This work describes the asymmetric synthesis of a new salen-type ligand via a Diels-Alder reaction and Curtius rearrangement. The ligand with a norbornane skeleton was used in the trimethylsilylcyanation of aldehydes, but the enantioselectivity was 55%ee. The norborane skeleton was cleaved to destroy this rigidity, and the eanatioselectivity was thereby increased to 85%ee.

• 出版日期2010-8
• 单位东华大学