Brain structural differences between 73-and 92-year olds matched for childhood intelligence, social background, and intracranial volume

作者：Ritchie Stuart J; Dickie David Alexander; Cox Simon R; Hernandez Maria del C Valdes; Sibbett Ruth; Pattie Alison; Anblagan Devasuda; Redmond Paul; Royle Natalie A; Corley Janie; Maniega Susana Munoz; Taylor Adele M; Karama Sherif; Booth Tom; Gow Alan J; Starr John M; Bastin Mark E; Wardlaw Joanna M; Deary Ian J

来源：Neurobiology of Aging, 2018, 62: 146-158.

DOI：10.1016/j.neurobiolaging.2017.10.005

• Aging
• Structural MRI
• Brain volume
• White matter hyperintensities
• Lesion mapping

Fully characterizing age differences in the brain is a key task for combating aging-related cognitive decline. Using propensity score matching on 2 independent, narrow-age cohorts, we used data on childhood cognitive ability, socioeconomic background, and intracranial volume to match participants at mean age of 92 years (n = 42) to very similar participants at mean age of 73 years (n = 126). Examining a variety of global and regional structural neuroimaging variables, there were large differences in gray and white matter volumes, cortical surface area, cortical thickness, and white matter hyperintensity volume and spatial extent. In a mediation analysis, the total volume of white matter hyperintensities and total cortical surface area jointly mediated 24.9% of the relation between age and general cognitive ability (tissue volumes and cortical thickness were not significant mediators in this analysis). These findings provide an unusual and valuable perspective on neurostructural aging, in which brains from the 8th and 10th decades of life differ widely despite the same cognitive, socioeconomic, and brain-volumetric starting points.

• 出版日期2018-2