Application of Synchrotron FTIR Techniques in Biomedical Fields

作者：Yan Jiaping; Shao Zhengzhong; Chen Xin^*; Huang Yufang

来源：Progress in Chemistry, 2008, 20(11): 1768-1778.

• synchrotron radiation light source
• infrared imaging
• cells
• proteins
• microstructural analysis

Synchrotron infrared light source, characterized with broadband, high brightness and resolution is widely used in biomedical fields. With the progress in imaging technique of FTIR microscopy, the scientists can detect biochemical changes in vivo with synchrotron FTIR in subcellular scale and preserve the cells in life feature. By analyzing the protein, nucleic acid and phospholipid components in animal, botanic tissues and cells qualitatively and quantitatively, the pathological changes of bone, the neurodegeneration, the progress of cancer cells and the nutrition in plants can be well understood. Furthermore, the controlled release of drugs and other biochemical processes can also be monitored by synchrotron FTIR. It is worth noting that the intermolecular vibrations of biomolecular assemblies lie in the long wavelength, the so-called far infrared region, where synchrotron FTIR can provide higher signal-to-noise ratio spectra compared with conventional FTIR with global light source.

• 出版日期2008-11
• 单位复旦大学