A novel pseudo-seven-component diastereoselective synthesis of lambda(5)-phosphanylidene bis(2,5-dioxotetrahydro-1H-pyrrole-3-carboxylates) via binucleophilic systems

作者：Alizadeh, Abdolali^*; Rostamnia, Sadegh; Zhu, Long-Guan

来源：Tetrahedron Letters, 2010, 51(36): 4750-4754.

DOI：10.1016/j.tetlet.2010.07.027

• Triphenylphosphine
• Dialkyl acetylenedicarboxylate
• Isocyanide
• TFA
• Pseudo-seven-component (7-CR) reaction
• Phosphanylidene

The unusual 1:2 intermediate, generated by the addition of triphenylphosphine (TPP) to dialkyl acetylenedicarboxylates (DAAD) was trapped during the reaction of a Ph3P/RN = C/DMAD binucleophilic system with TFA as an initial proton source in a pseudo-seven-component (7-CR) diastereoselective reaction to give lambda(5)-phosphanylidene bis(2,5-dioxotetrahydro-1H-pyrrole-3-carboxylates) with three stereogenic centers and a phosphorane group in good yields.

• 出版日期2010-9-8
• 单位浙江大学