Morphological modification of female bladder after prolonged use of soy-based diets

作者：Faria Tatiane da Silva; Soares Lavinia Leal; Medeiros Jorge L Jr; Boaventura Gilson T; Sampaio Francisco J B; Ramos Cristiane da Fonte^*

来源：Maturitas, 2009, 62(1): 42-46.

DOI：10.1016/j.maturitas.2008.10.010

• Transgenic soy
• Estradiol
• Cholesterol
• Bladder
• Collagen

Objectives: The aim of this study was to compare the effects of a prolonged use of organic and transgenic soy upon the lipid profile and the collagen/muscle ratio of the detrusor muscle of the bladder.
Methods: Wistar rats were fed three different diets from weaning until sacrifice (15 months old): control group (CG) casein-based diet: organic soy group (OSG) organic soy-based diet: genetically modified soy group (GMSG) transgenic soy-based diet.
Results: There was no difference in the food consumption or in the diet isoflavone components among the groups. Comparing to CG, both OSG and GMSG groups presented a significant (p < 0.05) reduction in the body weight, triglycerides, cholesterol and the smooth muscle of the detrusor and a significant (p < 0.05) increase of collagen fibers number of the detrusor muscle.
Conclusions: These findings call into question that, the prolonged use of soy-based diets can be deleterious to the bladder by altering the collagen/muscle ratio what can cause bladder dysfunctions similar with that occurring during menopause.

• 出版日期2009-1-20