Association between V gamma w2V delta 2 T cells and disease progression after infection with closely related strains of HIV in China

作者：Li Haishan; Peng Hong; Ma Pengfei; Ruan Yuhua; Su Bing; Ding Xinping; Xu Chen; Pauza C David; Shao Yiming^*

来源：Clinical Infectious Diseases, 2008, 46(9): 1466-1472.

DOI：10.1086/587107

Background. Human immunodeficiency virus ( HIV) infection and disease are accompanied by decreases in the absolute number and function of V(gamma)2V delta 2 T cells, suggesting that this subset of cells may play an important role in controlling disease. We performed a cross-sectional study involving HIV-infected former blood donors and assessed the association between V(gamma)2V delta 2 T cells and markers of disease progression. Methods. Changes in V(gamma)2V delta 2 T cell count and function were compared between HIV-infected individuals and healthy blood donors using the Mann-Whitney U test. The relationships between Vg2Vd2 T cell count, plasma viral load, and CD4 T cell count were analyzed using the Spearman correlation. Results. We found significant positive correlations between CD4 T cell count and both total Vg2Vd2 T cell count () and functional ( isopentenyl pyrophosphate-responsive) V(gamma)2V delta 2 T cell count (P < .001). We found significant reverse correlations between viral load and both total V(gamma)2V delta 2 T cell count (P < .05) and functional V(gamma)2V delta 2 T cell count (P < .05). Conclusions. The association of V(gamma)2V delta 2 T cells with disease progression in 146 HIV-infected participants supports the view that intact V(gamma)2V delta 2 T cell populations are important for controlling HIV disease.

• 出版日期2008-5-1
• 单位中国疾病预防控制中心性病艾滋病预防控制中心