Downregulation of a long noncoding RNA BANCR contributes to proliferation and metastasis of hepatocellular carcinoma cancer cells in vitro and in vivo

作者：Yu, Xiangyang; Zhang, Guozhi; Zhao, Peng; Cui, Mingxin; Wang, Changyou; He, Yanfang^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(3): 3304-3312.

• BANCR
• HCC
• IncRNA
• proliferation
• metastasis
• progression

BANCR, a recently found IncRNA, has been proved to have the ability to regulate proliferation and migration of malignant melanoma cells. An aberrant expression of BANCR was observed in Lung carcinoma, gastric cancer and colorectal cancer. However, the exact effects and molecular mechanisms of BANCR in hepatocellular carcinoma (HCC) progression are still unknown up to now. The present study aimed to determine the expression, roles and functional mechanisms of a long noncoding RNA BANCR in the progression of HCC. In our study, we found that the expression of BANCR was downregulated in HCC tissues or cell lines including Huh7, SMMC-7721 and HepG2 by qRT-PCR analysis. Then, gain- and loss-of-function studies indicated that cell proliferation and migration were greatly suppressed, and the apoptosis was increased when BANCR was ectopically-expressed in HCC cells. Furthermore, ectopic expression of BANCR was demonstrated to inhibit tumor growth and metastasis in vivo. Taken together, our study indicates that BANCR is significantly down-regulated in HCC and may be correlated with tumor progression.

• 出版日期2016
• 单位中国科学技术大学