Direct Resolution of the Enantiomers of Betaxolol and Related Intermediates, and Its Application

作者：Li Yong Hong; Huang Li Hua; Zhang Shu Sheng; Liu Hong Min^*

来源：Chromatographia, 2010, 71(11-12): 987-991.

DOI：10.1365/s10337-010-1615-9

• Column liquid chromatography
• S-Betaxolol
• Enantiomer separation
• Acetylated intermediates
• OJ-H chiral column

An OJ-H chiral column has been used for direct resolution of the enantiomers of betaxolol and related intermediates in the preparation of (S)-betaxolol. The enantiomers can be excellently resolved (R (S) > 2) within 9.4 min with high peak symmetry. The enantiomers of some acetylated intermediates, which cannot be resolved on an OD-H column, can also be resolved. The method is simple and suitable for routine determination of ee values in the preparation of (S)-betaxolol.

• 出版日期2010-6
• 单位郑州大学