Different photodegradation behavior of barnidipine under natural and forced irradiation

作者：Ioele Giuseppina; Oliverio Filomena; Andreu Inmaculada; De Luca Michele; Miranda Miguel A; Ragno Gaetano^*

来源：Journal of Photochemistry and Photobiology A: Chemistry , 2010, 215(2-3): 205-213.

DOI：10.1016/j.jphotochem.2010.08.019

• Barnidipine
• Photodegradation
• Derivative spectrophotometry
• HPLC
• ICH degradation test

An in depth study on photodegradation of barnidipine, a new 1,4-dihydropyridine antihypertensive drug, was performed by exposing the drug to natural and stressing light irradiation. A different degradation process and distribution of photoproducts under different light sources and irradiation power were demonstrated. Degradation kinetics, reactive excited states involved, transient species and photoproducts generated-were investigated. Exposure of barnidipine to forced irradiation caused a complex degradation pathway. Kinetics of this process was stitched by HPLC and spectrophotometry, demonstrating the formation of several by-products In contrast, the drug, under direct or indirect sunlight, underwent oxidation generating the pyridine derivative as the main photodegradation product, according to most of the drug congeners HPLC and derivative spectropho

• 出版日期2010-9-25