Association of the FAM13A rs7671167 polymorphism with COPD risk: a meta-analysis

作者：Feng, Wei; Li, Shaojun; Li, Fangwei; Song, Yang; Su, Xiaofan; Yang, Lan; Li, Manxiang^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(7): 13407-13417.

• COPD
• FAM13A
• polymorphism
• genetic
• meta-analysis

Background: It has been reported that FAM13A rs7671167 polymorphism might be associated with the risk of chronic obstructive pulmonary disease (COPD). Due to inconclusive results, we conducted this meta-analysis to clarify the effect of rs7671167 polymorphism on COPD susceptibility. Material/Methods: A systematic literature search was performed to find relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Publication bias, heterogeneity and sensitivity analysis were also assessed. Results: A total of 7 eligible studies with 2841 COPD cases and 3843 controls were retrieved in the analysis. The pooled results indicated a significant association between FAM13A rs7671167 polymorphism and COPD risk under all of the genetic models (T versus C: OR = 1.283, 95% CI = 1.093-1.506, P = 0.002; TT versus CC: OR = 1.616, 95% CI = 1.183-2.208, P = 0.003; TC versus CC: OR = 1.337, 95% CI = 1.098-1.679, P = 0.005; TT+TC versus CC: OR = 1.449, 95% CI = 1.133-1.854, P = 0.003; TT versus TC+CC: OR = 1.314, 95% CI = 1.092-1.580, P = 0.004). Subgroup analysis showed the similar results in Caucasians (T versus C: OR = 1.429, 95% CI = 1.080-1.890, P = 0.012) and Asians (T versus C: OR = 1.232, 95% CI = 1.007-1.506, P = 0.043). Conclusions: The results of this meta-analysis suggest that T allele of the FAM13A rs7671167 polymorphism might act as a significant risk factor for the development of COPD. Further large-scale and well-designed studies with different populations are still required to validate our findings.

• 出版日期2016
• 单位西安交通大学