Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains

作者：Westdijk Janny^*; Koedam Patrick; Barro Mario; Steil Benjamin P; Collin Nicolas; Vedvick Thomas S; Bakker Wilfried A M; van der Ley Peter; Kersten Gideon

来源：Vaccine, 2013, 31(9): 1298-1304.

DOI：10.1016/j.vaccine.2012.12.076

• Sabin IPV
• Oil-in water
• PagL
• AlOH3
• Replicon particles
• MPL

Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants.

• 出版日期2013-2-18