Association of matrix metalloproteinase-10 polymorphisms with susceptibility to pelvic organ prolapse

作者：Wang, Hong; Zhang, Zhi-Qiang; Wang, Shu-Zhen; Lu, Jun-Li; Wang, Xiao-Lan; Zhang, Zhen-Yu^*

来源：Journal of Obstetrics and Gynaecology Research, 2015, 41(12): 1972-1981.

DOI：10.1111/jog.12809

• genetic polymorphisms
• matrix metalloproteinase-10
• pelvic organ prolapse
• susceptibility

Aim: The aim of this study was to explore the correlation between genetic mutations in matrix metalloproteinase-10 (MMP-10) and susceptibility to pelvic organ prolapse (POP). @@@ Material and Methods: From September 2011 to December 2013, 263 subjects were recruited, including 91 patients with POP (case group) and 172 non-POP patients (control group). Total MMP-10 concentrations in serum were measured by enzyme-linked immunosorbent assay. The genotyping of MMP-10 was achieved by quantitative real-time polymerase chain reaction. All data were analyzed with SPSS 18.0. @@@ Results: We found that parity, menopause, history of total hysterectomy, and family history of POP were all significantly higher in the POP group than in the control group (P = 0.017, P = 0.046, P = 0.0029 and P < 0.001, respectively). Serum MMP-10 levels were obviously higher in the POP group than in the control group (P < 0.05). In addition, there was a statistically significant difference between the two groups in the distribution frequency of the MMP-10 (rs17435959G/C) genotype (P < 0.05). However, the distribution frequency of the MMP-10 (rs17293607C/T) genotype between the two groups showed no significant differences (P > 0.05). Furthermore, the patients with parity > 2 and postmenopausal women had elevated serum MMP-10 levels, and the patients with parity > 2 and postmenopausal women who carried the G/C+C/C genotype in the MMP-10 gene had an increased risk of POP. @@@ Conclusion: We support the view that the rs17435959 polymorphism of the MMP-10 gene may be associated with an increased risk of POP.

• 出版日期2015-12
• 单位首都医科大学; 煤炭总医院