Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication

作者：Unuma Kana; Harada Kazuki; Nakajima Makoto; Eguchi Hiromi; Tsushima Kensuke; Ito Takako; Shintani Ishida Kaori; Kojima Hideaki; Yoshida Ken ichi^*

来源：Forensic Science International, 2010, 194(1-3): E5-E8.

DOI：10.1016/j.forsciint.2009.09.003

• Central pontine myelinolysis
• Digoxin
• Vomiting
• Autopsy

An 87-year-old male, prescribed digoxin and furosemide for congestive heart failure and Alzheimer disease, had dehydration and anemia due to poor food intake and hemorrhagic cystitis. Repeated vomiting due to an upper respiratory infection caused disturbance of consciousness and hypotension. The patient was admitted to hospital and diagnosed with digoxin intoxication and hypernatremia. The serum sodium (Na+) level was corrected, but the patient died 4 days after admission following uncontrollable seizure. A histologic examination after an autopsy revealed characteristic findings of central pontine myelinolysis (CPM). This is the first autopsy report on CPM triggered by vomiting in association with digoxin administration.

• 出版日期2010-1-30