A Phytol-Enriched Diet Activates PPAR- in the Liver and Brown Adipose Tissue to Ameliorate Obesity-Induced Metabolic Abnormalities

作者：An Ji Yeong; Jheng Huei Fen; Nagai Hiroyuki; Sanada Kohei; Takahashi Haruya; Iwase Mari; Watanabe Natsumi; Kim Young Il; Teraminami Aki; Takahashi Nobuyuki; Nakata Rieko; Inoue Hiroyasu; Seno Shigeto; Mastuda Hideo; Kawada Teruo; Goto Tsuyoshi^*

来源：Molecular Nutrition & Food Research, 2018, 62(6): 1700688.

DOI：10.1002/mnfr.201700688

• adipocytes
• hepatocytes
• phytanic acid
• phytol
• PPAR-alpha

ScopePeroxisome proliferator-activated receptor alpha (PPAR-) is a ligand-activated transcription factor that regulates lipid and carbohydrate metabolism. We investigate the effects of naturally occurring PPAR- agonists, phytol, and its metabolite phytanic acid, on obesity-induced metabolic disorders using a mouse model.
Methods and resultsA luciferase reporter assay shows that phytanic acid potently activates PPAR- among PPAR subtypes. In high-fat-diet-induced, severely obese mice, a phytol-enriched diet increases phytanic acid levels in the liver and adipose tissue, where PPAR- is abundantly expressed. A phytol-enriched diet ameliorates severe obesity and the related metabolic abnormalities of white adipose tissue. Moreover, the expression of PPAR- target genes in the liver and brown adipose tissue is enhanced by a phytol-enriched diet, suggesting that phytol and phytanic acid activate PPAR- in these organs. We confirm that phytanic acid treatment induced PPAR- target gene expression in both primary hepatocytes and brown adipocytes from wild-type mice, but not in these cells from PPAR--deficient mice.
ConclusionA phytol-enriched diet may increase phytanic acid levels in the liver and brown adipocytes, thereby activating PPAR- in these organs and ameliorating obesity-induced metabolic diseases.

• 出版日期2018-3