Allergic complications from orthopaedic joint implants: the role of delayed hypersensitivity to benzoyl peroxide in bone cement

作者：Bircher Andreas^*; Friederich Niklaus F; Seelig Walter; Scherer Kathrin

来源：Contact Dermatitis, 2012, 66(1): 20-26.

DOI：10.1111/j.1600-0536.2011.01996.x

• benzoyl peroxide
• bone cement
• complication
• contact allergy
• dermatitis
• loosening
• orthopaedic implant
• pain
• patch tests
• swelling

Background. Orthopaedic implants and osteosynthesis materials are increasingly being used. Complications include mainly physicalmechanical problems and infections. Uncommonly, an allergic reaction towards an alloy metal or a bone cement component has been implicated. Potential bone cement allergens include acrylates, benzoyl peroxide, N,N-dimethyl-p-toluidine, and gentamicin. Typical symptoms are pain, swelling, inflammatory skin reactions, implant loosening, and fistula formation. %26lt;br%26gt;Objectives. To report on 5 patients with complications from a knee or a shoulder joint implant in whom a relevant sensitization to benzoyl peroxide was shown. %26lt;br%26gt;Methods. Patch tests were performed with the European baseline series, an extended metal series, and a bone cement series. Patch tests with benzoyl peroxide were performed twice in all patients. A bone cement-free replacement was chosen in sensitized patients. %26lt;br%26gt;Results. In 4 patients sensitized to benzoyl peroxide, a bone cement-free replacement resulted in a considerable decrease or disappearance of pain and swelling, and complete clearing of cutaneous symptoms. %26lt;br%26gt;Conclusions. Components of bone cement, such as benzoyl peroxide, may rarely cause allergic complications. However, because of the irritant potential of these substances, careful performance, reading and interpretation of the patch tests is required.

• 出版日期2012-1