Arginine-rich Peptides: Methods of Translocation Through Biological Membranes

作者：Futaki Shiroh^*; Hirose Hisaaki; Nakase Ikuhiko

来源：Current Pharmaceutical Design, 2013, 19(16): 2863-2868.

DOI：10.2174/1381612811319160003

• Cell-penetrating peptide
• arginine
• macropinocytosis
• membrane-associated proteoglycan
• direct translocation
• membrane potential
• counterion
• membrane curvature

Intracellular delivery using cell-penetrating peptides (CPPs) has received considerable attention as a promising method for introducing exogenous molecules into cells. The mechanisms that enable efficient internalization of CPPs together with cargo molecules are also of interest. In this review, we describe our current views of membrane translocation of CPPs, especially those rich in arginine, as these peptides represent one of the most frequently employed classes of CPPs.

• 出版日期2013-5