Mechanistic divergence of two closely related aldol-like enzyme-catalysed reactions

作者：Ahn M; Pietersma AL; Schofield LR; Parker EJ^*

来源：Organic and Biomolecular Chemistry, 2005, 3(22): 4046-4049.

DOI：10.1039/b511611a

The analysis of the interaction of threose 4-phosphate and 2-deoxyerythrose 4-phosphate with 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS) reveals previously unrecognised mechanistic differences between the DAH7PS-catalysed reaction and that catalysed by the closely related enzyme, 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS).

• 出版日期2005-11-21