A vertebrate-specific and essential role for osterix in osteogenesis revealed by gene knockout in the teleost medaka

作者：Yu Tingsheng; Graf Martin; Renn Joerg; Schartl Manfred; Larionova Daria; Huysseune Ann; Witten Paul Eckhard; Winkler Christoph^*

来源：Development, 2017, 144(2): 265-271.

DOI：10.1242/dev.139550

• Osteoblasts
• Osteogenesis
• Bone modelling
• Skeleton
• Medaka

osterix (osx; sp7) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here, we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally, supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Osx for bone formation in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation.

• 出版日期2017-1-15