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摘要
Background: Imaging modalities to assess atherosclerotic plaque thrombogenicity have not been established, so in this study the relationship between [F-18]-fluorodeoxyglucose (F-18-FDG) uptake and thrombus formation was investigated in rabbit atherosclerotic arteries. %26lt;br%26gt;Methods and Results: Atherosclerotic plaque was induced in the iliacofemoral artery by balloon injury and a 0.5% cholesterol diet. At 3 weeks after the first balloon injury, the arteries were visualized by 18F-FDG positron emission tomography (PET) imaging 2 h after an F-18-FDG infusion, and then arterial thrombus was induced by a second balloon injury of both iliacofemoral arteries. Imaging with F-18-FDG-PET revealed significantly more radioactivity along the injured (0.63 +/- 0.12 SUVmax), than the contralateral non-injured artery (0.34 +/- 0.08 SUVmax, n=17, P%26lt;0.0001). Arterial radioactivity measured by autoradiography positively correlated with macrophage area, the number of nuclei that were immunopositive for nuclear factor kappa B (NF-kappa B), and tissue factor (TF) expression. The immunopositive areas for glycoprotein IIb/IIIa and fibrin in thrombi were significantly larger in the atherosclerotic than in the contralateral arteries, and significantly correlated with radioactivity in PET (r=0.92, P%26lt;0.001, n=10) and autoradiography (r=0.73, P%26lt;0.0001, n=50) in the arteries. Inhibition of NF-kappa B significantly reduced TF expression in cultured atherosclerotic plaque. %26lt;br%26gt;Conclusions: Arterial F-18-FDG uptake reflects the thrombogenicity of atherosclerotic plaque following balloon injury.
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