Health-related quality of life is impaired in active collagenous colitis

作者：Hjortswang Henrik^*; Tysk Curt; Bohr Johan; Benoni Cecilia; Vigren Lina; Kilander Anders; Larsson Lasse; Taha Yesuf; Strom Magnus

来源：Digestive and Liver Disease, 2011, 43(2): 102-109.

DOI：10.1016/j.dld.2010.06.004

• Collagenous colitis
• Health
• Health-related quality of life
• Inflammatory bowel disease (IBD)
• Microscopic colitis
• Quality of life

Objectives: The characteristic clinical symptoms of collagenous colitis are non-bloody diarrhoea, urgency and abdominal pain. Treatment is aimed at reducing the symptom burden and the disease impact on patients' health-related quality of life. The objective of this study was to analyse health-related quality of life in patients with collagenous colitis.
Methods: In a cross-sectional, postal HRQL survey, 116 patients with collagenous colitis at four Swedish hospitals completed four health-related quality of life questionnaires, two disease-specific (Inflammatory Bowel Disease Questionnaire and Rating Form of IBD Patient Concerns), and two generic (Short Form 36, SF-36, and Psychological General Well-Being, PGWB), and a one-week symptom diary. Demographic and disease-related data were collected. Results for the collagenous colitis population were compared with a background population controlled for age and gender (n = 8931).
Results: Compared with a Swedish background population, patients with collagenous colitis scored significantly worse in all Short Form 36 dimensions (p < 0.01), except physical function. Patients with active disease scored worse health-related quality of life than patients in remission. Co-existing disease had an impact on health-related quality of life measured with the generic measures. Lower education level and shorter disease duration were associated with decreased well-being.
Conclusion: Health-related quality of life was impaired in patients with collagenous colitis compared with a background population. Disease activity is the most important factor associated with impairment of health-related quality of life. Patients in remission have a health-related quality of life similar to a background population.

• 出版日期2011-2