Assessing environmental and occupational risk factors for lung cancer in Mexican-Americans

作者：McHugh Michelle K; Kachroo Sumesh; Liu Mei; D'Amelio Anthony M Jr; Dong Qiong; Hong Waun Ki; Greisinger Anthony J; Spitz Margaret R; Etzel Carol J^*

来源：Cancer Causes & Control, 2010, 21(12): 2157-2164.

DOI：10.1007/s10552-010-9635-1

• Lung cancer
• Epidemiology
• Occupational and environmental risk factors
• Mexican Americans
• Pesticides
• Antimicrobial agents

Background We investigated environmental and occupational exposures and smoking history (while controlling for demographics) in a population of Mexican-American lung cancer cases and controls from the Houston metropolitan area.
Methods Data were collected between 1991 and 2005 as part of an on-going multi-racial/ethnic, lung cancer case-control study. Cases included 212 Mexican-American lung cancer cases from UT MD Anderson Cancer Center. Controls (n = 328) were recruited from Houston's largest multispecialty group practice and frequency matched to the cases by age (+/- 5 years), sex, and ethnicity. Environmental and occupational factors were analyzed and odds ratios and 95% confidence intervals were calculated using logistic regression.
Results We detected elevated risks of lung cancer associated with pesticide exposure and found conventional and antimicrobial (e. g., sterilizers, disinfectants, antiseptics) pesticides were associated with an increased risk of lung cancer in Mexican-Americans (conventional pesticides and antimicrobial pesticides combined: OR = 1.80, 95% CI 1.13-2.86; conventional pesticides: OR = 2.05, 95% CI 1.23-2.39; antimicrobial pesticides: OR = 2.48, 95% CI 1.46-4.21).
Conclusions Although we found over a two-fold increased risk of lung cancer among Mexican-Americans for pesticides, we could not identify individual pesticides. Our findings are an important preliminary step in identifying factors that are specifically associated with lung cancer risk among Mexican Americans.

• 出版日期2010-12