Does Matrix Metalloproteinase-3 Polymorphism Play a Role in Age-Related Macular Degeneration in Patients With Myocardial Infarction?

作者：Liutkeviciene Rasa^*; Zaliaduonyte Peksiene Diana; Zaliuniene Dalia; Gustiene Olivija; Jasinskas Vytautas; Lesauskaite Vaiva; Tamosiunas Abdonas; Zaliunas Remigijus

来源：Medicina-Lithuania, 2012, 48(8): 404-409.

• age-related macular degeneration
• myocardial infarction
• neovascularization
• matrix metalloproteinase-3 gene polymorphism

Objective. The aim of our study was to determine if the genotype of the matrix metalloproteinase-3 (MMP-3) gene might carry the risk of age-related macular degeneration (ARMD) in patients with myocardial infarction.
Material and Methods. A total of 499 patients with an acute myocardial infarction or with a history of myocardial infarction were enrolled into the study. They were subdivided into 2 groups: 273 patients with ARMD and 226 patients without ARMD. The control group comprised 560 persons from a random sample of the Lithuanian population. DNA was analyzed using real-time polymerase chain reaction to genotype polymorphism 5A/6A at a position - 1171 of the MMP-3 gene promoter.
Results. Of the 499 patients with myocardial infarction, 47% had early-stage ARMD. The patients with ARMD were older than the patients in the group without ARMD (62.1 +/- 10.8 vs. 59.6 +/- 11.1, P<0.01). The analysis of MMP-3 gene polymorphism did not reveal any differences in the distribution of 5A/5A, 5A/6A, and 6A/6A genotypes between the ARMD group, non-ARMD group, and the control group (24.2%, 52.5%, and 23.3% in the ARMD group; 28.7%, 51.9%, and 19.4% in non-ARMD group; and 25.7%, 49.3% and 25.0%, in the control group, respectively).
Conclusions. MMP-3 gene polymorphism had no predominant effect on the development of ARMD in patients with myocardial infarction.

• 出版日期2012