Antibodies Against the Tom40 Subunit of the Translocase of the Outer Mitochondrial Membrane Complex and Cognitive Impairment in Alzheimer%26apos;s Disease

作者：Kimura Akio^*; Sakurai Takeo; Yamada Megumi; Koumura Akihiro; Hayashi Yuichi; Tanaka Yuji; Hozumi Isao; Ohtaki Hirofumi; Chousa Mitsuhiro; Takemura Masao; Seishima Mitsuru; Inuzuka Takashi

来源：Journal of Alzheimer's Disease, 2012, 29(2): 373-377.

DOI：10.3233/JAD-2011-111343

• Antigen
• cognition
• dementia
• endothelial cell
• mitochondrion
• pathogenesis

Recent studies suggest that microvascular abnormalities are involved in pathology and progression of Alzheimer%26apos;s disease. The purpose of this study was to examine the presence of antibodies against cerebral microvascular endothelial cells specific for Alzheimer%26apos;s disease, and to evaluate the association of these antibodies with cognitive impairment. The study included patients with Alzheimer%26apos;s disease (age %26gt;= 60 years; 24 patients), control subjects without neurological diseases (age %26gt;= 60 years; 19 subjects), patients with multiple sclerosis (all ages; 17 patients), and healthy control subjects (age %26lt;40 years; 18 subjects). Serum was analyzed with 2-dimensional electrophoresis and Western blot, with cultured human brain microvascular endothelial cells as the antigen source. The anti-Tom40 antibody was identified significantly more frequently in patients with Alzheimer%26apos;s disease than control subjects or patients with multiple sclerosis. In patients with Alzheimer%26apos;s disease, the mean scores for the Mini-Mental State Examination were significantly lower for patients who were positive for anti-Tom40 antibody than those who were negative for anti-Tom40 antibody. In summary, the anti-Tom40 antibody is significantly associated with cognitive impairment in patients with Alzheimer%26apos;s disease.

• 出版日期2012