A case of acute hepatitis A infection in an HIV-positive patient despite complete hepatitis A vaccination

作者：Fritzsche Carlos^*; Loebermann M; Reisinger E C

来源：Infection, 2018, 46(4): 565-567.

DOI：10.1007/s15010-018-1129-1

• Hepatitis A
• Vaccine
• Infection
• HIV

Background Vaccination against hepatitis A virus infection is recommended for men who have sex with men and other risk groups. The protection offered by the combined hepatitis A and B vaccine is comparable to that offered by the monovalent hepatitis A vaccine.
Case A 38-year-old HIV-positive patient presented with right upper abdominal pain, fever and jaundice. Serological work-up and detection of hepatitis A RNA in stool sample revealed an acute hepatitis A infection despite a previous complete vaccination with the combined hepatitis A and B vaccine.
Conclusion Although the combined hepatitis A and B vaccine is associated with very good seroconversion rates, the effectiveness in HIV-positive patients is not ensured, even in cases with CD4 cell counts of > 500/mu l. Therefore, regular post-vaccine testing should be encouraged to assess seroconversion in immunocompromised subjects.

• 出版日期2018-8