科研之友
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摘要
The structure of a cocrystal between trimethoprim and 2-aminoterephthalic acid has revealed the formation of 3D-interpenetrated networks. Each network is composed of tubular columns, sharing walls. Within each column the molecules interact with each other to form either left or right handed triple-helical arrangements with channels of 8.8 x 7.4 angstrom(2) dimensions running along the axis of the triple helix. Adjacent strands of each triple helix are separated by a distance of 6.7 angstrom with the accompanying void space filled by interweaving of triple helices from an adjacent network. The helices of adjacent triple-helical network are connected by N-H center dot center dot center dot O hydrogen bonds and helices of different networks interact with each other by C-H center dot center dot center dot N hydrogen bonds.
- 出版日期2011
