Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis

作者：Feng, Qing Yang; Hu, Zi Xuan; Song, Xi Ling; Pan, Hong Wei^*

来源：International Journal of Ophthalmology, 2017, 10(6): 973-981.

DOI：10.18240/ijo.2017.06.22

• pterygium
• growth factors
• matrix metalloproteinases
• tissue inhibitors of metalloproteinases
• interleukins
• tumor suppressor genes
• proliferation and apoptosis
• cell adhesion molecules
• extracellular matrix proteins

Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of metalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. We illustrate their possible mechanisms in the pathogenesis of pterygium as well as the related intervention based on them for pterygium therapy.

• 出版日期2017-6-18
• 单位暨南大学