A Comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell line

作者：Mirakabad Fatemeh Sadat Tabatabaei; Akbarzadeh Abolfazl; Milani Morteza; Zarghami Nosratollah; Taheri Anganeh Mortaza; Zeighamian Vahideh; Badrzadeh Fariba; Rahmati Yamchi Mohammad^*

来源：Artificial Cells, Nanomedicine and Biotechnology, 2016, 44(1): 423-430.

DOI：10.3109/21691401.2014.955108

• breast cancer
• curcumin
• PLGA-PEG
• MTT assay

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women worldwide. Herbal medicines have tremendous potential as promising agents for the treatment of cancer. Curcumin is a natural polyphenol which has many anticancer effects. Because of its low aqueous solubility, low bioavailability, and quick degradation and metabolism, curcumin was released using PLGA-PEG nanoparticles. Herein, the efficiency of pure curcumin and curcumin-loaded PLGA-PEG in MCF-7 human breast cancer cell lines was studied. H-1 NMR, FT-IR and SEM demonstrated PLGA-PEG structure and curcumin loaded on nanoparticles. Subsequently, the cytotoxic effects of free curcumin and curcumin-loaded PLGA-PEG were determined via an MTT assay. Our study confirmed that curcumin-loaded PLGA-PEG has more cytotoxic effects on the MCF-7 breast cancer cell line and could be exploited as a potential source for developing novel drugs against breast cancer.

• 出版日期2016-1-2