New records in aerobic power among octogenarian lifelong endurance athletes

作者：Trappe Scott^*; Hayes Erik; Galpin Andrew; Kaminsky Leonard; Jemiolo Bozena; Fink William; Trappe Todd; Jansson Anna; Gustafsson Thomas; Tesch Per

来源：Journal of Applied Physiology, 2013, 114(1): 3-10.

DOI：10.1152/japplphysiol.01107.2012

• aging
• exercise
• heart rate
• oxygen consumption
• skeletal muscle

Trappe S, Hayes E, Galpin A, Kaminsky L, Jemiolo B, Fink W, Trappe T, Jansson A, Gustafsson T, Tesch P. New records in aerobic power among octogenarian lifelong endurance athletes. J Appl Physiol 114: 3-10, 2013. First published October 11, 2012; doi: 10.1152/japplphysiol.01107.2012.-We examined whole body aerobic capacity and myocellular markers of oxidative metabolism in lifelong endurance athletes [n = 9, 81 +/- 1 yr, 68 +/- 3 kg, body mass index (BMI) = 23 +/- 1 kg/m(2)] and age-matched, healthy, untrained men (n = 6; 82 +/- 1 y, 77 +/- 5 kg, BMI = 26 +/- 1 kg/m(2)). The endurance athletes were cross-country skiers, including a former Olympic champion and several national/regional champions, with a history of aerobic exercise and participation in endurance events throughout their lives. Each subject performed a maximal cycle test to assess aerobic capacity (VO2max). Subjects had a resting vastus lateralis muscle biopsy to assess oxidative enzymes (citrate synthase and beta HAD) and molecular (mRNA) targets associated with mitochondrial biogenesis [peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial transcription factor A (Tfam)]. The octogenarian athletes had a higher (P < 0.05) absolute (2.6 +/- 0.1 vs. 1.6 +/- 0.1 l/min) and relative (38 +/- 1 vs. 21 +/- 1 ml center dot kg(-1)center dot min(-1)) VO2max, ventilation (79 +/- 3 vs. 64 +/- 7 l/min), heart rate (160 +/- 5 vs. 146 +/- 8 beats per minute), and final workload (182 +/- 4 vs. 131 +/- 14 W). Skeletal muscle oxidative enzymes were 54% (citrate synthase) and 42% (beta HAD) higher (P < 0.05) in the octogenarian athletes. Likewise, basal PGC-1 alpha and Tfam mRNA were 135% and 80% greater (P < 0.05) in the octogenarian athletes. To our knowledge, the VO2max of the lifelong endurance athletes is the highest recorded in humans > 80 yr of age and comparable to nonendurance trained men 40 years younger. The superior cardiovascular and skeletal muscle health profile of the octogenarian athletes provides a large functional reserve above the aerobic frailty threshold and is associated with lower risk for disability and mortality.

• 出版日期2013-1