科研之友
微信
新浪微博
Facebook
分享链接
摘要
Breast cancer (BC) is the most common cancer among women worldwide. It has been estimated that approximately 12-20 % of patients will develop liver metastases from breast cancer (BCLM) and that in approximately 5 % of cases the liver is the only metastatic site. Patients with isolated BCLM have the poorest prognosis with a median survival ranging from 19 to 26 months. %26lt;br%26gt;A total of 26 women with isolated BCLM and without any sign of disease progression after a cycle of chemotherapy were retrospectively reviewed. Women were treated with hepatic resection (HR) for unilobar disease or surgical %26quot;open%26quot; RFA for bilobar disease. Data were collected on either original BC or BCLM and from patients follow-up. %26lt;br%26gt;Overall survival from BC diagnosis was 47.69 +/- A 22.25 months (range 33-84, median 45.5 months); it was 52.25 +/- A 14.57 months (range 33-84, median 48.5 months) for the HR patients and 43.79 +/- A 27.14 months (range 9-101, median 39 months) for the RFA patients. Overall survival from BCLM treatment was 21.12 +/- A 12.78 months (range 9-64, median 15.5 months); in detail it was 29.42 +/- A 14.53 months (range 12-64, median 29.5 months) for the resected patients and 14 +/- A 4.45 months (range 9-24, median 13.5 months) for patients treated by RFA with a strongly significant survival difference for operated patients (p = 0.001). Overall disease-free survival from BCLM was 15.96 +/- A 13.16 months (range 3-64, median 12 months), disease-free survival for resected patients was 23.22 +/- A 16.2 months (range 8-64, median 18.5 months), and for patients treated by RFA was 9.64 +/- A 4.22 months (range 3-18, median 9 months; Fig. 1). Overall 1, 2, and 5 years (actuarial) survival was respectively 80.7, 57, and 31 %. Given in details for the two groups, they were respectively 100, 66.6 and 34 % (actuarial) for the resected group patients and 64.2, 21.4, and 11.5 % (actuarial) for the RFA patients. %26lt;br%26gt;Aggressive treatment on isolated BCLM may improve survival for these patients.
- 出版日期2013-6
