Adiponectin: Its role in obesity-associated colon and prostate cancers

作者：Muppala Sntoshi; Konduru Siva K P; Merchant Neha; Ramsoondar Judy; Rampersad Carlos Karan; Rajitha Balney; Mukund Vidya; Kancherla Jyothsna; Hammond Anthea; Barik Tapan Kumar; Mannarapu Mastan; Alam Afroz; Basha Riyaz; Bramhachari Pallaval Veera; Verma Dheeraj; Sushma Pinninti Santosh; Pattnaik Subasini; Nagaraju Ganji Purnachandra

来源：Critical Reviews in Oncology/Hematology, 2017, 116: 125-133.

DOI：10.1016/j.critrevonc.2017.06.003

• Obesity
• Adiponectin
• Adiponectin receptors
• Colorectal cancer
• Prostate cancer

Adipose tissue synthesizes many proteins and hormones collectively called adipokines, which are linked to a number of diseases, including cancer. Low levels of adiponectin are reported to be a risk factor for obesity-related cancers including colorectal and prostate cancers. Accordingly, obesity/lifestyle-related diseases, including certain cancers, may be treated by developing drugs that act specifically on adiponectin levels in circulation. Adiponectin may also serve as a clinical biomarker in obesity-related diseases. Adiponectin-based therapies are known to inhibit cancer advancement and thus may provide a therapeutic approach to delay cancer progression. Better understanding of the function of adiponectin is of great significance in the fight against cancer. This timely review is concentrated on the role of adiponectin and the impact of obesity on the development of cancers, especially colorectal and prostate cancers.

• 出版日期2017-8