Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress

作者：Guzman Beltran Silvia; Espada Sandra; Orozco Ibarra Marisol; Pedraza Chaverri Jose^*; Cuadrado Antonio

来源：Neuroscience Letters, 2008, 447(2-3): 167-171.

DOI：10.1016/j.neulet.2008.09.079

• Heme oxygenase-1
• Nrf2
• Neuroprotection
• NDGA
• 3-Nitropropionic acid
• Antioxidant response elements

Because the etiopathology of neurodegenerative diseases is tightly connected with oxidative stress, there is an increasing need to find compounds that might elicit an antioxidant and neuroprotective response in neurons. We found that nordihydroguaiaretic acid (NDGA), a powerful antioxidant from Larrea tridentate, activates the antioxidant pathway Nrf2/heme oxygenase-1 (HO-1) in cerebellar granule neurons and protects them against H(2)O(2) or 3-nitropropionic acid-induced neurotoxicity. The role of HO-1 in this protective effect was made evident by using an HO inhibitor, tin-mesoporphyrin. Our study identifies NDGA as a new potential therapeutic tool to activate the Nrf2/HO-1 axis for protection against oxidative stress.

• 出版日期2008-12-12