New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson%26apos;s disease

作者：Calabresi Paolo^*; Castrioto Anna; Di Filippo Massimiliano; Picconi Barbara

来源：Lancet Neurology, 2013, 12(8): 811-821.

DOI：10.1016/S1474-4422(13)70118-2

Parkinson%26apos;s disease is a common progressive neurodegenerative disease, of which the main neuropathological hallmark is dopaminergic neuronal loss. Increased attention has been directed towards non-motor symptoms in Parkinson%26apos;s disease, such as cognitive impairment and behavioural disorders. Clinical and experimental findings support the view that the hippocampus, a temporal lobe structure involved in physiological learning and memory, is also implicated in the cognitive dysfunction seen in some patients with Parkinson%26apos;s disease. Moreover, emerging data suggest interactions between the dopaminergic systems and the hippocampus in synaptic plasticity, adaptive memory, and motivated behaviour. This structure is also implicated in the pathophysiology of other non-motor symptoms, such as impulse control disorders, anosmia, and fatigue. Evidence from clinical observations and experimental studies suggest a complex hippocampal cross-talk among the dopaminergic and other transmitter systems. Furthermore, neurotrophic factors might interact with the hippocampal dopaminergic system having possible implications on the non-motor symptoms seen in patients with Parkinson%26apos;s disease.

• 出版日期2013-8