科研之友
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摘要
Platinum-based drugs are widely used as a master key in the multiple cancer therapies, while limited by the adverse side effects during the in vivo circulation. To settle the aforementioned problems, we prepare a series of polymer-platinum conjugates by utilizing the "stealth" polyethylene glycol and legumain-cleavable oligopeptide. @@@ We select MGC803 cells overexpressing the legumain and MKN28 cells negatively expressing the legumain as well as the normal stomach cells to compose the test groups. @@@ In vitro cytotoxicity studies indicate the polymer-platinum conjugates with the assistance of Ala-Ala-Asn tripeptide can effectively inhibit the growth of MGC-803 cells than control groups. Meanwhile, the MPEG polymer show better anticancer ability than 4-arm-PEG polymer. However, in the group of MKN28 cells, both polymer-platinum conjugates express weak cytotoxicity due to lacking of the mediation of legumain. @@@ Hence, the synthesized polymer-platinum conjugates exhibiting great potential in avoiding the side effects and enhancing the therapy ability will be valuable for the platinum-cancer therapy.
