科研之友
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摘要
The reaction of 3-nucleofugal phthalides with 2-amidoacrylates is shown to provide a synthesis of densely substituted naphth[2,1-d] oxazoles in good yields. It is proposed to proceed via a five-step cascade which includes phthalide annulation, demethoxycarbonylation, and heterocyclization. The methodology is free from regiochemical ambiguity of the products. In certain cases, the corresponding 2-amidonaphthoquinones are directly formed.
- 出版日期2016-4
