Antiprotozoal alkaloids from Galanthus trojanus

作者：Kaya Gulen Irem; Sarikaya Buket; Onur Mustafa Ali; Somer Nehir Unver^*; Viladomat Francesc; Codina Carles; Bastida Jaume; Lauinger Ina L; Kaiser Marcel; Tasdemir Deniz

来源：Phytochemistry Letters, 2011, 4(3): 301-305.

DOI：10.1016/j.phytol.2011.05.008

• Galanthus trojanus
• Amaryllidaceae
• Antimalarial activity
• Alkaloid N-oxides

Two new alkaloid N-oxides, 1-O-acetyldihydromethylpseudolycorine N-oxide, and 11-hydroxyvittatine N-oxide, ten known alkaloids; arolycoricidine, haemanthamine, O-methylnorbelladine, narcidine, dihydrolycorine, 8-O-demethylmaritidine, stylopine and protopine, nicotinic acid and tyramine were isolated from Galanthus trojanus A. P. Davis & N. Ozhatay (Amaryllidaceae). The chemical structures of the isolates were elucidated by UV, IR, MS, CD, 1D and 2D NMR experiments. The in vitro antiprotozoal and cytotoxic potentials of the compounds were also evaluated.

• 出版日期2011-9