An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles

作者：Ali Akbar; Correa Arlene G; Alves Diego; Zukerman Schpector Julio; Westermann Bernhard; Ferreira Marco A B; Paixao Marcio W^*

来源：Chemical communications, 2014, 50(80): 11926-11929.

DOI：10.1039/c4cc04678a

A simple and efficient metal-free methodology for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles has been developed by applying a novel inverse electron-demand-1,3-dipolar cycloaddition approach. The practical one-pot metal-free strategy can be accomplished with various alkylidene malononitriles and aromatic azides in the presence of base.

• 出版日期2014