Neurocognitive outcome in young adults born late-preterm

作者：Heinonen Kati^*; Lahti Jari; Sammallahti Sara; Wolke Dieter; Lano Aulikki; Andersson Sture; Pesonen Anu-Katriina; Eriksson Johan G.; Kajantie Eero; Raikkonen Katri

来源：Developmental Medicine and Child Neurology, 2018, 60(3): 267-274.

DOI：10.1111/dmcn.13616

AimThis study examined whether late-preterm birth (34+0 to 36+6wks+d gestational age) was associated with neurocognitive deficit in young adulthood, and whether small for gestational age (SGA) birth amplified any adversity.
MethodParticipants derived from the prospective regional cohort study, the Arvo Ylppo Longitudinal Study (n=786; 398 females, 388 males) (mean age 25y 4mo, SD 8mo), born 1985 to 1986 late-preterm (n=119; 21 SGA, <-2 SD) and at term (37+0 to 41+6wks+d; n=667; 28 SGA) underwent tests of intelligence, executive functioning, attention, and memory, and reported their education.
ResultsThose born late-preterm scored -3.71 (95% confidence interval [CI] -6.71 to -0.72) and -3.11 (95% CI -6.01 to -0.22) points lower on Full-scale and Verbal IQ than peers born at term. Compared with those born at term and appropriate for gestational age (-2 to <2 SD) Full-scale, Verbal, and Performance IQ scores of those born late-preterm and SGA were -9.45 to -11.84 points lower. After adjustments, differences were rendered non-significant, except that scores in Full-scale and Performance IQ remained lower among those born late-preterm and SGA.
InterpretationLate-preterm birth, per se, may not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and SGA seems to increase this risk.

• 出版日期2018-3