Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways

作者：Doi Kunio^*; Uetsuka Koji

来源：International Journal of Molecular Sciences, 2011, 12(8): 5213-5237.

DOI：10.3390/ijms12085213

• neurotoxicity
• T-2 toxin
• macrocyclic trichothecenes
• fumonisin B-1
• ochratoxin A

Among many mycotoxins, T-2 toxin, macrocyclic trichothecenes, fumonisin B-1 (FB1) and ochratochin A (OTA) are known to have the potential to induce neurotoxicity in rodent models. T-2 toxin induces neuronal cell apoptosis in the fetal and adult brain. Macrocyclic trichothecenes bring about neuronal cell apoptosis and inflammation in the olfactory epithelium and olfactory bulb. FB1 induces neuronal degeneration in the cerebral cortex, concurrent with disruption of de novo ceramide synthesis. OTA causes acute depletion of striatal dopamine and its metabolites, accompanying evidence of neuronal cell apoptosis in the substantia nigra, striatum and hippocampus. This paper reviews the mechanisms of neurotoxicity induced by these mycotoxins especially from the viewpoint of oxidative stress-associated pathways.

• 出版日期2011-8