alpha-Methoxymethyl ketones via aldol reaction

作者：Kasal Alexander^*; Budesinsky Milos

来源：Tetrahedron, 2013, 69(46): 9663-9674.

DOI：10.1016/j.tet.2013.09.022

• NMR
• Steroids
• Synthesis
• Aldol reaction

Paraformaldehyde in a methanolic solution of KOH converts ketones into alpha-methoxymethylated and alpha- hydroxymethylated products. The method was tested on nine steroidal ketones. On prolonged treatment the ketones formed are reduced to alcohols.

• 出版日期2013-11-18