Mitochondrial Mechanisms of Apoptosis in Response to DNA Damage

作者：Glazunova V A^*; Shtil A A

来源：Molecular Biology, 2008, 42(5): 681-686.

DOI：10.1134/S0026893308050051

• mitochondria
• caspases
• DNA
• apoptosis
• eukaryotic cells

Genome integrity is essential for cell viability, while damage to the DNA structure is a key factor inducing cell death. Among all cell death programs, those involving mitochondrial proteins are of particular importance. Activation of various protective epigenetic mechanisms in response to DNA damage prevents cell death. The outcome of genotoxic stress-cell death versus survival-depends on the balance of proapoptotic and antiapoptotic signaling. This concept provides a rational basis for improving the efficacy of anticancer therapy by combining DNA-damaging exposures with inhibition of antiapoptotic mechanisms.

• 出版日期2008-10