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摘要
An efficient asymmetric vinylogous allylic alkylation of beta, gamma-butenolides with Morita-Baylis-Hillman carbonates has been developed. With a chiral cyclohexane-based squaramide-phosphine catalyst 5e, optically active gamma, gamma-disubstituted butenolides containing adjacent quaternary and tertiary chiral centers have been constructed in good-to-excellent yields (up to 98%) and excellent stereoselectivities (87 : 13-99 : 1 dr, 96-99% ee).
- 出版日期2015
- 单位华东理工大学
