科研之友
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摘要
Objective: To determine whether the proportion of incomplete resection of cervical intraepithelial neoplasia (GIN 1-3) may be reduced by CIN Excisor compared with loop excision of the transformation zone (LLETZ).
Study design: A prospective trial during a 2-year period at a district general hospital in London, United Kingdom, including 420 women scheduled for treatment due to CIN, after colposcopy guided biopsy results. This study was expected to demonstrate a statistically significant difference (p < 0.05) in the proportion of women with clear histopathological resection margins after treatment with GIN Excisor compared with LLETZ. Chi-square or Fisher's exact test were used to compare histopathological resection margins in the GIN Excisor and LLETZ groups.
Results: Overall, there is strong evidence of a difference in the proportion of histopathological specimens with clear resection margins for the GIN Excisor group, compared with the LLETZ group (201/210, 95.7% versus 180/210, 85.7%: p < 0.001). Sub-analysis within the two groups, of the proportion of histopathological specimens with clear resection margins in relation to CIN grades, revealed a statistically significant difference in favour of the GIN Excisor group for CIN 1 (99/103, 96.1% versus 82/95, 86.3%: p = 0.01), and GIN 2 (73/77, 94.8% versus 68/80, 85%: p = 0.04). There is a numerical difference in the proportion of clear resection margins in favour of the GIN Excisor for GIN 3 (29/30, 96.7% versus 30/35, 85.7%), but this difference was not statistically significant (p = 0.21). Perioperative complications were similar between the two groups.
Conclusion: GIN Excisor achieved better results than LLETZ for treatment of GIN 1-3 with respect to clear histopathological resection margins. However, further studies including a larger number of women treated for GIN 3 are needed before firm conclusions are drawn.
- 出版日期2010-7
