Do Changes in Circulating Biomarkers Track With Each Other and With Functional Changes in Older Adults?

作者：Sanders Jason L^*; Ding Victoria; Arnold Alice M; Kaplan Robert C; Cappola Anne R; Kizer Jorge R; Boudreau Robert M; Cushman Mary; Newman Anne B

来源：Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2014, 69(2): 174-181.

DOI：10.1093/gerona/glt088

• Biomarkers
• Epidemiology
• Functional performance
• Longevity
• Inflammation

Background. It is unclear if changes in proposed circulating biomarkers of aging are strongly correlated to each other or functional change. We tested if biomarker changes track with each other and with functional measures over 9 years in older adults. %26lt;br%26gt;Methods. Dehydroepiandrosterone sulfate (DHEAS), adiponectin, insulin-like growth factor 1 (IGF-1), IGF binding proteins 1 (IGFBP-1) and 3 (IGFBP-3), interleukin-6 (IL-6), cholesterol, and gait speed, grip strength, Modified Mini Mental Status Exam [3MSE] and Digit Symbol Substitution Test [DSST] scores) were measured in 19961997 and 2005-2006 in the Cardiovascular Health Study All Stars study (N = 901, mean [standard deviation, SD] age 85.3 [3.6] years in 2005-2006). Adjusted Pearson correlations illustrated if biomarkers tracked together. Multivariable linear regression demonstrated if biomarker changes tracked with functional changes. %26lt;br%26gt;Results. Correlations among biomarker changes were mostly %26lt; 0.2. In models with each biomarker entered separately, a 1-SD increase biomarker change was associated with change in function as follows: grip strength (DHEAS beta = 0.61 kg, p =.001; IL-6 beta = -0.46 kg, p =.012; cholesterol men beta = 0.79 kg, p =.016); gait speed (DHEAS beta = 0.02 meters per second, p =.039; IL-6 beta = -0.018 meters per second, p =.049); and DSST score (DHEAS women beta = 1.46, p =.004; IL-6 beta = -0.83, p =.027). When biomarkers were entered in the same model, significant associations remaining were as follows: grip strength (DHEAS beta = 0.54 kg, p =.005; IL-6 beta = -0.43 kg, p =.022); 3MSE score (IGF-1 beta = 0.96, p =.04; IGFBP-3 beta = -1.07, p =.024); and DSST score (DHEAS women beta = 1.27, p =.012; IL-6 beta = -0.80, p =.04). %26lt;br%26gt;Conclusion. Changes in biomarkers were poorly correlated, supporting a model of stochastic, independent change across systems. DHEAS and IL-6 tracked most closely with function, illustrating that changes in inflammation and sex steroids may play dominant roles in changes of these functional outcomes.

• 出版日期2014-2