Extracellular Vesicles in Chronic Obstructive Pulmonary Disease

作者：Kadota Tsukasa; Fujita Yu; Yoshioka Yusuke; Araya Jun; Kuwano Kazuyoshi; Ochiya Takahiro^*

来源：International Journal of Molecular Sciences, 2016, 17(11): 1801.

DOI：10.3390/ijms17111801

• COPD
• extracellular vesicles
• exosome
• microRNA
• microvesicle
• pathogenesis
• biomarker
• therapy
• exacerbation
• endothelial microparticle

Chronic obstructive pulmonary disease (COPD) is characterized by the progression of irreversible airflow limitation and is a leading cause of morbidity and mortality worldwide. Although several crucial mechanisms of COPD pathogenesis have been studied, the precise mechanism remains unknown. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from almost all cell types and are recognized as novel cell-cell communication tools. They have been shown to carry and transfer a wide variety of molecules, such as microRNAs, messenger RNAs, and proteins, which are involved in physiological functions and the pathology of various diseases. Recently, EVs have attracted considerable attention in pulmonary research. In this review, we summarize the recent findings of EV-mediated COPD pathogenesis. We also discuss the potential clinical usefulness of EVs as biomarkers and therapeutic agents for the treatment of COPD.

• 出版日期2016-11