Mutual Interaction and Reciprocal Down-Regulation Between c-met and Insulin Receptor Substrate-1

作者：Deangelis Tiziana; Morrione Andrea; Baserga Renato^*

来源：Journal of Cellular Physiology, 2010, 224(3): 658-663.

DOI：10.1002/jcp.22164

The insulin receptor substrate-1 (IRS-1) and c-met, the receptor for the hepatocyte growth factor (HGF) co-immuno-precipitate from lysates treated with the respective antibodies. The interaction between IRS-1 and c-met requires a tyrosyl phosphorylated IRS-1 and results in reciprocal down-regulation. IRS-1 inhibits cell motility, while the activated c-met promotes it. These and other results suggest an explanation for reports in the literature indicating that c-met levels are high and IRS-1 levels are low in human cancer metastases. J. Cell. Physiol. 224: 658-663, 2010.

• 出版日期2010-9