摘要
Objective: To explore how the global organization or topology of the functional brain connectivity (FBC) is affected in Down Syndrome (DS). Methods: As the brain is a highly complex network including numerous nonlinearly interacted neuronal areas, the FBCs of typically developing (TD) children and DS patients were computed using a nonlinear synchronization method. Then the differences in global organization of the obtained FBCs of the two groups were analyzed, in all electroencephalogram (EEG) frequency bands, in the framework of Small-Worldness Network (a network with optimum balance between segregation and integration of information). Results: The topology of the functional connectivity of DS patients is disrupted in the whole brain in alpha and theta bands, and especially in the left intra-hemispheric brain networks in upper alpha band. Conclusions: The global organization of the DS brain does not resemble a Small-World network, but it works as a random network. Significance: It is the first study on global organization of the FBC in DS.
- 出版日期2013-9